endothelium injury

*neutrophil-endothelium interaction
The Accumulation and infiltration of inflammatory leukocytes, specifically neutrophils, at sites of injury contribute to the cytotoxity of vital tissues and result in organ dysfunction.
*nitric oxide
NO is derived from endothelial surfaces in response to acetylcholine stimulation, hypoxia,endotoxin,cellular injury, or mechanical shear stress from circulating blood. NO also can reduce microthrombosis by reducing platelet adhesion and aggregation.
*prostacyclin
It is an arachidonate product.
*endothelins
*platelet-activating factor
*atrial natriuretic peptides